Cytotoxic, apoptotic, and necrotic effects of silver nanoparticles biosynthesized using Origanum majorana extract

Nanotechnology has gained great interest due to its widespread application. Anticancer activity of Origanum majorana extract and silver nanoparticles was investigated by MTT assay using human pancreatic adenocarcinoma cell lines (Capan-1), mouse normal fibroblast (L929), colon line (Caco-2). AgNPs@Om exhibited the excellent cytotoxic effect on Capan-1 with viability 29.17% 25.70%, 22.49%, 21.16% at 1.0, 0.5, 0.25, 0.125 µg/mL respectively. However, determined show moderate activity. A considerable fall in viable number Caco-2 observed after treatment AgNPs@Om. The cells were detected as 32.0% 1.0 nanoparticles. Yet, 48.2% O. extract. Both had no impact non-tumor (L929). Moreover, induced apoptosis. Consequently, may be a promising anticancer drug candidate.